FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to pharmaceutics and medicine, and concerns a pharmaceutical composition for prevention and treatment of thrombosis, containing (A) N1-(5-chloropyridin-2-yl)-N2-((1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-{[(5-methyl-4,5,6,7-tetrahydrothiazol[5,4-c]pyridin-2-yl)carbonyl]amino}cyclohexyl)ethandiamine, its pharmaceutically acceptable salt or hydrate, (B) sugar alcohol which is mannitol, xylitol or erythritol, and (C) a water-swellable additive.
EFFECT: composition has higher water solubility.
18 cl, 8 dwg, 4 tbl, 4 ex
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