METHOD OF DETERMINING CONTENT OF HYDROXYMETHYL QUINOXYLINE DIOXIDE AND IMPURITIES THEREOF BY HPLC Russian patent published in 2014 - IPC G01N30/34 

FIELD: chemistry.

SUBSTANCE: determination is carried out by high performance liquid chromatography (HPLC) on a C18 column measuring 50×3.0 mm, filled with a carrier with grain size of 3.0 mcm, or measuring 150×4.6 mm, filled with a carrier with grain size of 5.0 mcm, using as the mobile phase a mixture of water and acetonitrile in ratio of 90:10 to 95:5 or a mixture of 0.3% methanoic acid solution and acetonitrile in ratio of 90:10 to 95:5 and acetonitrile in linear gradient mode on a chromatograph using a UV detector.

EFFECT: high accuracy of determining content of hydroxymethyl quinoxyline dioxide and impurities thereof in a substance and in a medicinal drug containing same.

3 cl, 8 dwg, 4 tbl