NOVEL BICYCLIC HETEROCYCLIC COMPOUND Russian patent published in 2014 - IPC C07D235/14 C07D403/06 C07D403/12 C07D405/06 C07D405/12 C07D405/04 C07D405/14 C07D471/04 A61K31/4184 A61K31/437 A61K31/4439 A61K31/454 A61K31/496 A61K31/5377 A61P13/00 A61P19/02 A61P25/00 A61P25/04 A61P43/00 

Abstract RU 2518073 C2

FIELD: chemistry.

SUBSTANCE: claimed invention relates to novel compound of formula (1) or its pharmaceutically acceptable salt, possessing SNS inhibiting properties. In general formula R1 represents (1) hydrogen atom, (2) halogen atom, (3) C1-6alkyl group or (4) C1-6halogenalkyl group (where R1 can be present in any substitutable position of benzene or pyridine ring); L represents (1) simple bond, (2) -O- or (3) -CH2O- (where L can be present in position 5 or 6 of condensed cycle); R2 represents (1) C6-10aryl group (C6-10aryl group is optionally condensed with C3-6cycloalkane), optionally substituted with substituent(s), X represents carbon atom or nitrogen atom. Other values of radicals are given in the invention formula.

EFFECT: obtaining compounds which can be used to prepare medication for treatment or prevention of such diseases as neuropathic pain, nociceptive pain, dysuria, disseminated sclerosis, etc.

19 cl, 47 tbl, 237 ex

Similar patents RU2518073C2

Title Year Author Number
CONDENSED HETEROCYCLIC DERIVATIVE, THERAPEUTIC COMPOSITION WHICH CONTAINS IT AND ITS APPLICATION IN MEDICINE 2006
  • Okhno Kokhsuke
  • Mijagi Takasi
  • Ozava Tomonaga
  • Fusimi Nobukhiko
RU2418803C2
DERIVATIVES OF 5-AMIDINO-2-HYDROXYBENZENESULFONAMIDE, PHARMACEUTICAL COMPOSITIONS COMPRISING THEREOF AND INTERMEDIATE COMPOUNDS FOR THEIR PREPARING 2001
  • Okazaki Kosuke
  • Utida Masakhiko
  • Mukajjama Kharunobu
  • Kobajasi Khiroaki
  • Kai Juitiro
  • Takeuti Khideki
  • Ekojama Kendzi
  • Terao Esikhiro
  • Khojano Judzi
  • Siokhara Khiroaki
  • Kikuti Norikhiko
RU2273633C9
2-PYRIDONE DERIVATIVES 2010
  • Kavaguti Takanori
  • Vatatani Kengo
  • Fusegi Kejko
  • Bokhno Masakhiro
  • Asanuma Khadzime
  • Kuroda Soiti
  • Imai Judai
  • Tonan Tomomiti
  • Sato Nagaaki
  • Tokita Sigeru
  • Sasako Sigetada
  • Okada Takumi
  • Khajasi Keisi
  • Itokh Sin
  • Saito Noriko
  • Dzibiki Rui
  • Isijama Seisi
  • Ota Khirofumi
RU2551847C2
AMIDOCARBOXYLIC ACID DERIVATIVES, PHARMACEUTICAL COMPOSITION BASED THEREON AND METHOD OF REDUCING GLUCOSE IN BLOOD 1998
  • Janagisava Khiroaki
  • Sakuraj Mitsuja
  • Takamura Makoto
  • Fudzivara Tosikhiko
RU2176999C2
ANTITUMOUR COMPOUNDS 2008
  • Rodriges Visente Al'Berto
  • Garranso Garsia-Ibarrola Marija
  • Mursija Peres Karmen
  • Sanches Sancho Fransisko
  • Kuehvas Marchante Marija Del' Karmen
  • Mateo Urbano Kristina
  • Digon Khuares Isabel'
RU2493147C2
SIGMA-RECEPTOR INHIBITORS 2005
  • Laggner Kristian
  • Kuberes-Altisent Marija Rosa
  • Kholents Jorg
  • Berrokal'-Romero Khuana Marija
  • Kontikhoch-L'Obet Marija Montserrat
RU2417987C2
BENZENE DERIVATIVES 1994
  • Nobukhiro Okhi
  • Tatsuja Kato
  • Tomokazu Ozaki
RU2127254C1
PIPERAZINE-SUBSTITUTED BENZOTHIOPHENES FOR TREATING PSYCHIATRIC DISORDERS 2006
  • Jamasita Khirosi
  • Matsubara Dzun
  • Osima Kunio
  • Kuroda Khideaki
  • Ito Nobuaki
  • Mijamura Sin
  • Simizu Satosi
  • Tanaka Tatsuesi
  • Takakhasi Kharuka
RU2402549C2
INDOLE DERIVATIVE AND ITS PHARMACEUTICAL APPLICATION 2010
  • Inoue Terukhiko
  • Kajja Tetsudo
  • Kikuti Siniti
  • Matsumura Kodzi
  • Masuo Ritsuki
  • Sudzuki Motoja
  • Maekava Mitikhide
RU2556216C2
QUINOLONE DERIVATIVES AND PHARMACEUTICAL COMPOSITION 2008
  • Otsubo Kendzi
  • Oti Judzi
  • Nakai Masami
  • Mori Atsusi
RU2490259C2

RU 2 518 073 C2

Authors

Tsuboi Katsunori

Jamai Jusuke

Vatanabe Khitosi

Kinosita Khironori

Dates

2014-06-10Published

2009-12-25Filed