ANTITUMOUR COMPOUNDS Russian patent published in 2013 - IPC C07C231/12 C07C235/34 C07C237/42 C07F7/18 A61K31/165 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of general formula (I), where Y is selected from -CR_ay=CR_by- and -CHR_ay-CR_by=CR_cy-; each R_ay, R_by and R_cy is independently selected from a hydrogen atom and unsubstituted C₁-C₁₂ alkyl; each R₁, R₂, R₃, R₄ and R₅ is independently selected from a hydrogen atom and unsubstituted C₁-C₁₂ alkyl; R₆ is selected from NR₈R₉ and OR₁₀; W is selected from NR₇; R₇ is a hydrogen atom; R₈ is a hydrogen atom; R₁₀ is an unsubstuted C₂-C₁₂ alkenyl; R₉ is a substituted C₂-C₁₂ alkenyl which is substituted in one or more positions by a halogen , OR', OCONHR' and OH, protected by a silyl ether, where R' is hydrogen; each of R₁₁, R₁₂, R₁₃, R₁₄ and R₁₅ is independently selected from a hydrogen atom, OR_a, OSiR_aR_bR_c; and each R_a, R_b and R_c is independently selected from a hydrogen atom and unsubstituted C₁-C₁₂ alkyl. The invention also relates to a pharmaceutical composition having cytotoxic activity, which contains said compounds, use of compounds of formula (I) to prepare a medicinal agent for treating cancer and methods of producing compounds of formula (I).

EFFECT: compounds having cytotoxic activity.

23 cl, 10 dwg, 2 tbl, 10 ex