FIELD: chemistry.
SUBSTANCE: invention relates to use of compounds, characterised by formulae (I) and (IB), or pharmaceutically acceptable salts thereof, isomers or hydrates to prepare a medicinal agent for treating or preventing diseases or conditions mediated by the sigma-receptor, selected from psychosis, neuropathic pain or inflammatory pain and movement disorder, such as dystonia or tardive dyskinesia, motor defects, including allodynia/or hyperalgesia. Radicals and symbols in compounds of formulae (I) and (IB) are described in claims 1 and 2. The invention also relates to novel compounds of formulae (I') and (IB'), in which radicals and symbols are described in claims 4 and 5, having pharmacological activity on the sigma-receptor, methods of producing such compounds, a pharmaceutical composition containing said compounds and use of said compounds in preparing a medicinal agent for treating and/or preventing diseases or conditions whose development involves the sigma-receptor. (I), (IB) (I') and (IB').
EFFECT: high effectiveness of the inhibitors.
22 cl, 1 tbl, 3 dwg, 64 ex
Title | Year | Author | Number |
---|---|---|---|
1,2,4-TRIAZOLE DERIVATIVES AS SIGMA RECEPTOR INHBITORS | 2007 |
|
RU2451015C2 |
PYRAZOLE COMPOUNDS AS SIGMA RECEPTOR INHIBITORS | 2011 |
|
RU2582338C2 |
SIGMA-RECEPTOR INHIBITORS | 2005 |
|
RU2404972C2 |
N,N-SUBSTITUTED 3-AMINOPYRROLIDINE COMPOUNDS EFFECTIVE AS MONOAMINE REUPTAKE INHIBITORS | 2006 |
|
RU2574406C2 |
USE OF SIGMA LIGANDS FROM PAIN IN BONE CANCER | 2011 |
|
RU2585095C2 |
GLYCOLATOXIDASE INHIBITORS FOR THE TREATMENT OF DISEASES | 2018 |
|
RU2805308C2 |
PYRAZOL DERIVATIVES, MEDICAL COMPOSITIONS, CONTAINING THEM, THEIR APPLICATION IN MEDICINE AND INTERMEDIATE COMPOUNDS FOR THEIR PRODUCTION | 2003 |
|
RU2369613C2 |
SPIROCYCLIC AMINE DERIVATIVES AS S1P MODULATORS | 2011 |
|
RU2602800C2 |
NITROGEN-CONTAINING AROMATIC DERIVATIVES, PHARMACEUTICAL COMPOSITION CONTAINING THEREOF, METHOD FOR TREATMENT AND USING | 2003 |
|
RU2310651C2 |
SIGMA-LIGANDS FOR APPLICATION IN PREVENTION AND/OR TREATMENT OF POSTOPERATIVE PAIN | 2011 |
|
RU2569055C2 |
Authors
Dates
2011-05-10—Published
2005-08-29—Filed