INDOLE DERIVATIVE AND ITS PHARMACEUTICAL APPLICATION Russian patent published in 2015 - IPC C07D401/14 C07D403/04 C07D403/14 C07D405/14 C07D413/14 C07D417/14 C07D471/04 A61K31/416 A61K31/4178 A61K31/422 A61K31/427 A61K31/433 A61K31/437 A61K31/4439 A61K31/454 A61K31/496 A61K31/5377 A61K31/55 A61P29/00 A61P19/02 A61P37/06 A61P37/08 

Abstract RU 2556216 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to compound, represented by the following formula

,

or its pharmaceutically acceptable salt. In claimed formula each symbol has values, determined in formula of invention. Versions of formula [I] compound and particular compounds are also objects of invention. In addition, invention relates to pharmaceutical composition, ITK inhibitor and means for treatment or prevention of inflammatory diseases, allergic diseases, autoimmune diseases, transplant rejection and other diseases and methods of treating said diseases.

EFFECT: claimed compounds inhibit induced T-cellular kinase (ITK).

32 cl, 86 tbl, 387 ex

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RU 2 556 216 C2

Authors

Inoue Terukhiko

Kajja Tetsudo

Kikuti Siniti

Matsumura Kodzi

Masuo Ritsuki

Sudzuki Motoja

Maekava Mitikhide

Dates

2015-07-10Published

2010-11-25Filed