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(19)

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2 664 197

(13)

(51)

IPC

C07K14/595(2006-01-01)

C07K16/28(2006-01-01)

A61K38/16(2006-01-01)

A61K39/00(2006-01-01)

A61K39/39(2006-01-01)

A61P3/04(2006-01-01)

A61P5/00(2006-01-01)

(21) (22)

Application

2015154795, 2014-05-16

(24)

Start date

2014-05-16

(22)

Actual filing date

2014-05-16

(45)

Published

2018-08-15

(72)

Inventor

Brume, Pol KristoferDzhejkobs, Frederik UilyamLanger, KristofMyudde, Gert Kornelius

(73)

Holder

Tiuajdzhi Onkolodzhi Ltd.

IMMUNOGENIC COMPOSITION, VACCINE COMPRISING SAME, KIT FOR PREPARING SAID COMPOSITION AND METHOD OF TREATING DISEASES ASSOCIATED WITH GASTRIN SECRETION PATHOLOGY Russian patent published in 2018 - IPC C07K14/595 C07K16/28 A61K38/16 A61K39/00 A61K39/39 A61P3/04 A61P5/00

Abstract RU 2664197 C2

FIELD: biotechnology.

SUBSTANCE: invention relates to biotechnology, specifically to immunogenic compositions of gastrin-17, and can be used in medicine to treat diseases associated with the pathology of gastrin secretion. Immunogenic composition includes a) a first component containing an adjuvant which contains an anti-CD32 moiety linked to a TLR9 ligand and a first peptidic alpha-helix, and b) a second component containing at least one gastrin-17 peptide immunogen linked to a second peptidic alpha-helix. Said first peptidic alpha-helix of the first part is coiled with the second peptidic alpha-helix of the second part, thereby forming a coiled spiral structure.

EFFECT: invention makes it possible to increase the effectiveness of immunisation against gastrin-17, overcoming the natural immunological tolerance against the autologous antigen G17M.

15 cl, 3 dwg, 2 tbl, 7 ex

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RU 2 664 197 C2

Authors

Brume, Pol Kristofer

Dzhejkobs, Frederik Uilyam

Langer, Kristof

Myudde, Gert Kornelius

Dates

2018-08-15—Published

2014-05-16—Filed