APPLICATION OF HSP70 AS REGULATOR OF ENZYMATIC ACTIVITY Russian patent published in 2014 - IPC C07K14/46 A61K38/17 A61P3/00 

Abstract RU 2521672 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to the field of biotechnology. The claimed invention relates to the field of modulation of enzymatic activity by application of interaction between a molecular chaperone Hsp70 and lysosomal phospholipid bis(monoacylglycero)phosphate (BMP). The invention can be used in medicine.

EFFECT: interaction of Hsp70-BMP modulates activity of lysosomal compartment enzymes, interacting with BMP, therefore the claimed invention represents means of reversing pathology of lysosomal storage diseases.

21 cl, 16 dwg, 2 tbl, 3 ex

Similar patents RU2521672C2

Title Year Author Number
USE OF HSP70 AS ENZYME ACTIVITY REGULATOR 2009
  • Jensen Tomas Kirkegor
  • Jotella Mar'Ja Khelena
RU2571946C2
GENETIC CONSTRUCT FOR EXPRESSION IN LYSOSOMES OF MAMMALIAN CELLS OF RHODOPSIN NsXeR FROM ORGANISM NANOHALOARCHAEON NANOSALINA, WHICH ENABLES TO INCREASE pH OF LYSOSOMES 2023
  • Ilinskij Nikolaj Sergeevich
  • Bukhalovich Sergej Mikhajlovich
  • Gordelij Valentin Ivanovich
  • Tsybrov Fedor Mikhajlovich
  • Alekseev Aleksej Alekseevich
  • Nesterov Semen Valerevich
  • Bogorodskij Andrej Olegovich
  • Bagaeva Diana Fanovna
  • Borshchevskij Valentin Ivanovich
  • Vlasova Anastasiya Dmitrievna
  • Rogachev Andrej Vyacheslavovich
  • Mikhajlov Anatolij Eduardovich
RU2820973C1
TARGETED THERAPEUTIC LYSOSOMAL ENZYME FUSION PROTEINS AND USES THEREOF 2013
  • Aoyagi-Skarber Mika
  • Kristianson Tereza Margaret
  • Dvorak-Evell Melita
  • Vendt Deniel Dzh.
  • Long Shinong
  • Lebovits Dzhonatan
  • Gold Deniel Solomon
RU2680581C2
INTRAVENTRICULAR DELIVERY OF ENZYMES IN LYSOSOMAL STORAGE DISEASES 2014
  • Dodzh Dzhejms
  • Passini Marko
  • Shikhabuddin Lamya
  • Chen Sen
RU2665381C2
INTRAVENTRICULAR DELIVERY OF ENZYMES IN CASE OF LYSOSOMAL STORAGE DISEASES 2007
  • Dodzh Dzhejms
  • Passini Marko
  • Shikhabuddin Lamja
  • Chehn Sehn
RU2529830C2
METHOD FOR IDENTIFYING COMPOUNDS FOR TREATING CANCER 2010
  • Soehngas Gonsales Marija Soledad
  • Tormo Karul'Ja Damija
RU2575828C2
METHODS AND COMPOSITIONS FOR CNS DELIVERY OF IDURONATE-2-SULFATASE 2011
  • Chzhu Gaochzhun
  • Loue Kris
  • Shakhrokkh Zakhra
  • Kristian Dzhejms
  • Farner Rik
  • Pan Tszin
  • Rajt Teresa Leakh
  • Kalias Perikls
RU2660348C2
METHODS AND COMPOSITIONS FOR DELIVERY OF IDURONATE-2-SULPHATASE TO CNS 2011
  • Chzhu Gaochzhun
  • Loue Kris
  • Shakhrokkh Zakhra
  • Kristian Dzhejms
  • Farner Rik
  • Pan Tszin
  • Rajt Teresa Leakh
  • Kalias Perikls
RU2774112C2
THERAPEUTIC TARGETED FUSION PROTEINS BASED ON LYSOSOMAL ENZYMES, RELEVANT COMPOSITIONS AND THEIR APPLICATIONS 2017
  • Moshashaee Saeed
  • Pinkstaff Jason K.
  • Shaywitz Adam
  • Ciaccio Natalie
RU2751235C2
COMPOUND CONTAINING THERAPEUTIC ENZYME AND TRANSPORT ELEMENT CONNECTED TO EACH OTHER DIRECTLY OR BY USING LINKER 2022
  • Shukurov Rakhim Rakhmankulyevich
  • Reshetnik Elizaveta Vyacheslavovna
  • Khamitov Ravil Avgatovich
  • Shuster Aleksandr Mikhajlovich
RU2811100C1

RU 2 521 672 C2

Authors

Jensen Tomas Kirkegor

Jottela Mar'Ja Khelena

Dates

2014-07-10Published

2009-06-26Filed