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(19)

RU

(11)

2 704 232

(13)

C2

(51)

IPC

C07K16/24(2006-01-01)

C07K16/46(2006-01-01)

C12N15/13(2006-01-01)

A61K39/395(2006-01-01)

A61P37/00(2006-01-01)

(21) (22)

Application

2012108416, 2012-03-05

(24)

Start date

2003-11-07

(22)

Actual filing date

2012-03-05

(45)

Published

2019-10-24

(72)

Inventor

Silans KarenLoverejs MarkDe Khard Khans

(73)

Holder

Ablinks N.V.

SINGLE-DOMAIN ANTIBODIES DIRECTED AGAINST TUMOUR NECROSIS FACTOR ALPHA, AND USE THEREOF Russian patent published in 2019 - IPC C07K16/24 C07K16/46 C12N15/13 A61K39/395 A61P37/00 

Abstract RU 2704232 C2

FIELD: medicine.

SUBSTANCE: present invention relates to immunology. Disclosed is a polypeptide construct capable of specifically binding tumour necrosis factor alpha (TNF-alpha) containing two or four antagonists of single-domain antibodies directed against TNF-alpha, and one single-domain antibody directed against whey protein. Besides, it contains composition and coding nucleic acid.

EFFECT: present invention can be used in therapy of disorders associated with inflammatory processes or autoimmune diseases.

12 cl, 18 dwg, 11 tbl, 9 ex

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RU 2 704 232 C2

Authors

Silans Karen

Loverejs Mark

De Khard Khans

Dates

2019-10-24—Published

2012-03-05—Filed

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