FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to the field of biotechnology and deals with a method of obtaining a liquid fraction, which contains isolated highly molecular capsular polysaccharides of Streptococcus pneumoniae. The claimed method includes obtaining a fermentation culture of bacterial cells Streptococcus pneumoniae of serotypes 19A, 6A, 19F or 6B, producing the capsular polysaccharides, which include a phosphodiether bond between the repeated units, introduction of CO2 into the fermentation culture; lysis of bacterial cells with obtaining the liquid fraction, which contains the said polysaccharides, isolation of the capsular polysaccharides from the cell lysate with obtaining the liquid fraction of the isolated highly molecular capsular polysaccharides with a molecular weight of 480 kDa.
EFFECT: claimed inventions can be used in production of vaccines for immunisation against diseases, caused by Streptococcus pneumoniae.
14 cl, 3 dwg, 7 tbl, 1 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF OBTAINING SOLUTION, WHICH CONTAINS HIGHLY MOLECULAR ISOLATED CAPSULAR POLYSACCHARIDES OF STREPTOCOCCUS PNEUMONIAE SEROTYPE 19A (VERSIONS) | 2009 |
|
RU2511404C2 |
| ACCELERATED METHOD OF PURIFICATION FOR OBTAINING CAPSULAR POLYSACCHARIDES OF STREPTOCOCCUS PNEUMONIAE | 2008 |
|
RU2516340C2 |
| STREPTOCOCCUS PNEUMONIAE CAPSULAR POLYSACCHARIDES AND CONJUGATES THEREOF | 2015 |
|
RU2743793C1 |
| STREPTOCOCCUS PNEUMONIAE CAPSULAR POLYSACCHARIDES AND CONJUGATES THEREOF | 2015 |
|
RU2688831C2 |
| STREPTOCOCCUS PNEUMONIAE CAPSULE POLYSACCHARIDE AND ITS IMMUNOGENIC CONJUGATE | 2019 |
|
RU2803122C2 |
| MULTIVALENT COMPOSITION OF PNEUMOCOCCAL POLYSACCHARIDE-PROTEIN CONJUGATE | 2007 |
|
RU2484846C2 |
| CAPSULAR POLYSACCHARIDES OF STREPTOCOCCUS PNEUMONIAE AND THEIR CONJUGATES | 2015 |
|
RU2805417C1 |
| MULTIVALENT COMPOSITION OF PNEUMOCOCCAL POLYSACCHARIDE-PROTEIN CONJUGATE | 2007 |
|
RU2493870C2 |
| METHOD OF PRODUCING IMMUNOGENIC CONJUGATE OF CAPSULAR POLYSACCHARIDE STREPTOCOCCUS PNEUMONIAE-CARRIER PROTEIN | 2015 |
|
RU2710393C2 |
| C-POLYSACCHARIDE-FREE CAPSULAR POLYSACCHARIDES OF STREPTOCOCCUS PNEUMONIAE WITH A 2,5-ANHYDROMANOSE RESIDUE AT THE REDUCING END | 2023 |
|
RU2818894C1 |
