STREPTOCOCCUS PNEUMONIAE CAPSULE POLYSACCHARIDE AND ITS IMMUNOGENIC CONJUGATE Russian patent published in 2023 - IPC C07K14/315 A61K39/09 A61P31/04 

FIELD: immunology.

SUBSTANCE: invention relates to an immunogenic composition and its use. The following is provided: an immunogenic composition for preventing an infection, disease, or condition caused by Streptococcus pneumoniae in a subject, the said composition comprising an effective amount of 24 different Streptococcus pneumoniae capsular polysaccharide-protein conjugates, each capsular polysaccharide-protein conjugate containing a carrier protein conjugated with a capsular polysaccharide isolated from another serotype of Streptococcus pneumoniae. The serotypes of Streptococcus pneumoniae were selected from serotypes 1, 2, 3, 4, 5, 6A, 6B, 7F, 8, 9N, 9V, 10A, 11A, 12F, 14, 15B, 17F, 18C, 19A, 19F, 20, 22F, 23F and 33F. Capsular polysaccharides from serotypes 1 and 5 are conjugated with tetanus toxoid, and capsular polysaccharides from serotypes 2, 3, 4, 6A, 6B, 7F, 8, 9N, 9V, 10A, 11A, 12F, 14, 15B, 17F, 18C, 19A, 19F, 20, 22F, 23F, and 33F are conjugated to CRM197. A vaccine containing the said immunogenic composition is also provided. A method of preventing an infection, disease, or condition caused by Streptococcus pneumoniae in a subject and a method of inducing an immune response to Streptococcus pneumoniae in a subject, comprising administering the said immunogenic composition or the said vaccine to the subject are also provided.

EFFECT: invention provides a wide spectrum of protection against Streptococcus pneumoniae.

12 cl, 15 tbl, 2 ex