FIELD: medicine.
SUBSTANCE: group of inventions refers to medicine and concerns using a peptide conjugated with a protein representing a keyhole limpet hemocyanin (KLH) protein used as an immunogen for preparing antibodies specifically recognising any of prevailing versions of beta-amyloid peptide Aβ40 and Aβ42; or using an antibody, or an active fragment, or an antibody derivative of the above peptide in preparing a therapeutic agent for preventing and/or treating a disease characterised by amyloid accumulation in the patient's brain.
EFFECT: group of inventions provides effective immunisation, reduces an amyloid load and a quantity of brain amyloid plaques.
5 cl, 3 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF TREATING ALZHEIMER'S DISEASE | 2004 |
|
RU2385161C2 |
| ANTIBODY, SET AND METHOD OF DETERMINATION OF AMILOIDNY PEPTIDES | 2012 |
|
RU2571213C2 |
| IMPROVED PROTOFIBRIL-SELECTIVE ANTIBODIES AND USE THEREOF | 2007 |
|
RU2429244C2 |
| THERAPEUTIC VACCINE | 2006 |
|
RU2440824C2 |
| ANTI-AMYLOID BETA (A BETA) 1-42 MONOCLONAL ANTIBODIES POSSESSING THERAPEUTIC PROPERTIES | 2006 |
|
RU2551782C2 |
| PEPTIDE VACCINE FOR PREVENTION AND IMMUNOTHERAPY OF ALZHEIMER-TYPE DEMENTIA | 2013 |
|
RU2811687C2 |
| HIGH-SENSITIVITY IMMUNOASSAYS AND KITS FOR DETECTING PEPTIDES AND PROTEINS OF INTEREST | 2007 |
|
RU2461837C2 |
| MONOCLONAL BODY AGAINST AMYLOID BETA | 2008 |
|
RU2571856C2 |
| ACTIVE IMMUNISATION FOR CREATING SOLUBLE A-BETA ANTIBODIES | 2004 |
|
RU2390350C2 |
| MONOCLONAL ANTIBODIES AND APPLICATIONS THEREOF | 2006 |
|
RU2432362C2 |
