FIELD: chemistry.
SUBSTANCE: invention relates to novel inhibitors of human poly(ADP-riboso)polymerase-1 based on uracyl derivatives of general formula (I), (II), (III) and (IV). Inhibitors of poly(ADP-riboso)polymerase-enzymes take part in DNA reparation. In general formula 
and 
R1=H, Cl, Br, I, methyl, ethyl, propyl or isopropyl; R2, R3, R4, R5=H, methyl, ethyl, propyl or phenyl; R6=(CH2)n, where n=1-4; X=OR2 or NR2R3, R2, R3=H, methyl, ethyl, propyl, phenyl, 3-hydroxypropyl.
EFFECT: obtaining novel inhibitors of human poly(ADP-riboso)polymerase-1.
1 tbl, 19 ex
| Title | Year | Author | Number |
|---|---|---|---|
| MIMETICS OF POLY (ADP-RIBOSE) AND PROCESS FOR PRODUCING THEREOF | 2011 |
|
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|
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|
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|
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| COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR TREATING VIRAL INFECTIONS | 2007 |
|
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|
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