MIMETICS OF POLY (ADP-RIBOSE) AND PROCESS FOR PRODUCING THEREOF Russian patent published in 2015 - IPC C07H19/04 C12N15/00 A61K31/7084 A61K31/7088 

FIELD: chemistry.

SUBSTANCE: invention relates to PAR mimetics and method of obtaining thereof for the synthesis of novel medical drugs of formula

where Y - nucleotide residue, amine derivative of an aliphatic compound, fluorescence dye; Z - nucleoside residue, (k+1)·m = 1-200; X is O or S; R₁ and R₂ are residues of a disacharide nucleoside or a residue of formulas

wherein n = 2-6; 2-6 or 1-4 respectively, N = nucleoside residue, or -((CH₂)_nO)_m-(P = X(OH))O-N-, wherein n = 2-6, m = 1-6, R₃ is a branching agent of formula

wherein N′- disacharide nucleoside residue, n - a number up to 100, or residues of formulas

n = 2-6; or n = 2-6; or n = 1-4,

wherein B = adenine-9-yl, uracyl-1-yl, cytosine-1-yl or guanine-9-yl.

EFFECT: novel PAR mimetics, maintaining all key functional groups and spaces between them, required for the reaction with proteins, wherein the said mimetics are modified for the purpose of synthesis and stability.

2 cl, 21 ex, 2 tbl, 10 dwg