DIARYL ETHERS Russian patent published in 2014 - IPC C07D403/14 A61K31/4178 A61P31/14 

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of formula (I), to its possible stereoisomers, or to its pharmaceutically acceptable salts, where R and R¹, independently on each other, represent benzoyl, substituted with one substituent, each of which is independently selected from halogen or -C(=O)-Het, where Het is optionally substituted with two substituents, independently selected from C_1-4alkyl, or a group of formula -C(=O)-CH(R^x)-R⁶, C_1-6alkyloxycarbonyl, a group of formula R⁸-O-C(=O)-HN-CH(R⁷)-C(=O)- or -C(=O)-C(=O)-phenyl; R⁶ represents C_1-4alkyl, C_3-6cycloalkyl, benzyl or phenyl, where phenyl can be optionally substituted with one, two or three substituents, each of which is independently selected from halogen, C_1-6alkyl, methoxy, trifluoromethoxy, or two substituents at adjacent atoms of the ring together with a phenyl ring form benzodioxol, and where C_1-4alkyl is substituted with diC_1-6alkylamino, phenylsulphonyl, Het, and where benzyl is substituted with one substituent, each of which is independently selected from halogen, methoxy; R^x is selected from hydrogen, hydroxyl, diC_1-6alkylamino, imidazolyl, Het represents a heterocyclic group, containing one or two heteroatoms, selected from O and N, and containing 5-6 atoms in a ring, where the said heterocyclic ring is bound with the carbonyl carbon atom through the ring carbon atom and where at least one of the said heteroatoms is adjacent to the said ring carbon atom, R² and R³, independently on each other represent hydrogen; R⁴ and R⁵, independently on each other represent hydrogen or methoxy; each R⁷ independently represents phenyl or C_1-4alkyl optionally substituted with methoxy; and R⁸ represents C_1-4alkyl. The invention also relates to particular compounds and a pharmaceutical composition based on formula (I) compound.

EFFECT: obtained are novel compounds, useful as HCV inhibitors.

11 cl, 4 tbl, 49 ex