METHOD FOR PREPARING ALKYLBENZYLDIMETHYLAMMONIUMFLUORIDES POSSESSING ANTIVIRAL AND ANTIBACTERIAL ACTION Russian patent published in 2014 - IPC A61K31/137 C07C22/08 A61P31/04 A61P31/12 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to preparing alkylbenzyldimethylammoniumfluorides possessing antiviral and antibacterial action. The declared method consists in a reaction of a mixture of 1.5 M alkyl iodide of formula RJ, wherein R represents alkyl C₈H₁₇-C₁₈H₃₇, in absolute alcohol with dimethylbenzylamine at boiling; that is followed by a sequential ethanol stripping in vacuum, resolution of a residue in ethyl acetate, drying in diethyl ester, separation of an oil-precipitated intermediate product and residual ester stripping. The intermediate product is resolved in mixed ethanol and water in volume ratio 1:1 and titred in 10% aqueous AgF until iodide ions disappear from the solution; the solution is filtered, and the filter is boiled down, and crystallised from mixed methanol and hexane.

EFFECT: method provides preparing effective low-toxic therapeutic agent.

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