Show metadata Hide metadata

(19)

(11)

2 475 498

(13)

(51)

IPC

C07K14/795(2006-01-01)

C07F15/02(2006-01-01)

A61K38/41(2006-01-01)

A61K31/555(2006-01-01)

(21) (22)

Application

2011146831/04, 2011-11-17

(24)

Start date

2011-11-17

(22)

Actual filing date

2011-11-17

(45)

Published

2013-02-20

(72)

Inventor

Nebol'Sin Vladimir Evgen'EvichZheltukhina Galina AleksandrovnaOkorochenkov Sergej Aleksandrovich

(73)

Holder

Obshchestvo S Ogranichennoj Otvetstvennost'Ju

NOVEL HEMIN DERIVATIVES HAVING ANTIBACTERIAL AND ANTIVIRAL ACTIVITY Russian patent published in 2013 - IPC C07K14/795 C07F15/02 A61K38/41 A61K31/555

Abstract RU 2475498 C1

FIELD: chemistry.

SUBSTANCE: invention relates to novel hemin derivatives of general formula (I) where R₁ and R₂ both represent ArgNH₂, Arg(NO₂)OMe, GlyNH₂, SerNH₂, SerOH, GlyOH, Glu(OH)OH, Glu(ArgNH₂)ArgNH₂, Glu(SerOMe)SerOMe, Glu(NHCH₂CH₂OH)NHCH₂CH₂OH, Glu(SerNH₂)SerNH₂, Glu(GlyNH₂)GlyNH₂ or Glu(GlyOMe)GlyOMe; Meⁿ⁺ represents Fe²⁺ or Fe³⁺; Hal^- represents F^-, Cl^-, Br^- or I^-, or a pharmaceutically acceptable salt thereof. Also disclosed are a pharmaceutical composition, a medicinal agent and a method of producing compounds of general formula (I) (versions).

EFFECT: novel hemin derivatives disclosed herein have high water-solubility, antibacterial and antiviral activity without toxicity.

28 cl, 1 dwg, 4 tbl, 18 ex

Similar patents RU2475498C1

Title	Year	Author	Number
HEMIN DERIVATIVES, HAVING ANTIMICROBIAL ACTIVITY OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, SYNTHESIS METHOD, PHARMACEUTICAL COMPOSITION AND USE	2009	Nebol'Sin Vladimir Evgen'Evich Zheltukhina Galina Aleksandrovna Okorochenkov Sergej Aleksandrovich	RU2415868C1
CYCLIC HEMIN DERIVATIVE WITH ANTIMICROBIAL PROPERTIES AND METHOD FOR SYNTHESIS THEREOF	2018	Nebolsin Vladimir Evgenevich Zheltukhina Galina Aleksandrovna Blagodarov Sergej Valerevich	RU2656595C1
HEMIN DERIVATIVES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, METHOD OF OBTAINING, COMPOSITION AND APPLICATION	2007	Nebol'Sin Vladimir Evgen'Evich Zheltukhina Galina Aleksandrovna Lobanova Tat'Jana Nikolaevna Nosik Nikolaj Nikolaevich Nosik Dmitrij Nikolaevich Zheltukhin Sergej Leonidovich	RU2404191C2
METHOD FOR MICRO-DILUTION IN LIQUID MEDIUM FOR EVALUATING AND DETERMINING MINIMUM INHIBITORY CONCENTRATION OF ANTIBACTERIAL POLYPEPTIDES	2017	Shukh, Rejmond	RU2754667C2
COMPOUNDS AND METHODS FOR TREATMENT OF INFECTIONS	2018	Pejdzh Stefen Garg Sandzhaj Kinen Martin Makklaski Adam Stivens Endryu	RU2779024C2
COMPOUNDS AND METHODS OF TREATING INFECTIONS	2014	Pejdzh Stefen Garg Sandzhaj Kinen Martin Makklaski Adam Stivens Endryu	RU2666540C2
METHODS OF TREATING BACTERIAL INFECTIONS	2014	Pejdzh Stefen Garg Sandzhaj	RU2666605C2
DERIVATIVES OF HEMIN AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, METHOD FOR PREPARING, APPLICATION AND PHARMACEUTICAL COMPOSITION	2002	Evstigneeva R.P. Zheltukhina G.A. Zarubina T.V. Nebol'Sin V.E. Nosik D.N. Nosik N.N.	RU2238950C2
HEMIN-PEPTIDES, THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, PHARMACEUTICAL COMPOSITION AND USING AS ANTI-TUMOR AGENTS	2004	Nebol'Sin Vladimir Evgen'Evich Zheltukhina Galina Aleksandrovna Lobanova Tat'Jana Nikolaevna	RU2280649C1
MIXED METAL COMPLEXES BASED ON 5-(4-METHYLPHENYL)-2,2'-BIPYRIDINE AND (TETRAFLUOR) SALICYLIC ACIDS, HAVING ANTIBACTERIAL AND FUNGISTATIC ACTIVITY	2020	Shchur Irina Viktorovna Burgart Yanina Valerevna Shchegolkov Evgenij Vadimovich Gerasimova Natalya Avenirovna Evstigneeva Natalya Petrovna Zilberberg Natalya Vladimirovna Kopchuk Dmitrij Sergeevich Zyryanov Grigorij Vasilevich Kungurov Nikolaj Vasilevich Saloutin Viktor Ivanovich Chupakhin Oleg Nikolaevich	RU2737435C1

RU 2 475 498 C1

Authors

Nebol'Sin Vladimir Evgen'Evich

Zheltukhina Galina Aleksandrovna

Okorochenkov Sergej Aleksandrovich

Dates

2013-02-20—Published

2011-11-17—Filed