FUSED IMMUNOGLOBULIN PROTEINS Russian patent published in 2014 - IPC C07K16/42 C07K19/00 A61K38/16 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to the field of biochemistry, in particular to a polypeptide, which is capable, when fused with a biologically active polypeptide, of increasing its half-life time in serum, as well as to its application for increasing the half-life time in the circulation of erythropoietin, the stimulation factor of granulocyte colony, p40 and a receptor of the tumour necrosis factor. Disclosed are a molecule of nucleic acid, coding the said polypeptide, containing it expression vector, as well as a method of obtaining the said polypeptide by an introduction of a nucleic acid molecule, which codes it, into a mammalian host cell, its growth, as well as collection of the expressed polypeptide.

EFFECT: invention makes it possible to increase the time of half-life of the biologically active polypeptide in serum in an efficient way.

15 cl, 9 dwg, 1 tbl, 8 ex