FIELD: chemistry.
SUBSTANCE: described is a novel way of regiospecific synthesis of 1-[di(4-cyanophenyl)methyl]-1,2,4-triazole by reacting 4-amino-1,2,4-triazole with di(4-cyanophenyl)-halogenmethane and the obtained 4-amino-1-[di(4-cyanophenyl)methyl]-1,2,4-triazolium-1 salt is quantitatively deamidated with sodium nitrite in hydrochloric acid.
EFFECT: obtaining a compound I with high output and high degree of purity without further purification.
5 cl, 2 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF PRODUCING DI(4-CYANOPHENYL)METHANE | 2013 |
|
RU2527473C1 |
| METHOD OF PRODUCING DI(4-CYANOPHENYL)BROMOMETHANE | 2013 |
|
RU2530496C1 |
| METHOD OF SYNTHESIS OF ETHYL-ALPHA-2-DICHLORO-5-[4-(DIFLUORO-METHYL)-4,5-DIHYDRO-3- METHYL-5-OXO-1H-1,2,4-TRIAZOLE-1-YL]-4-FLUOROBENZENE PROPIONATE | 1996 |
|
RU2179552C2 |
| 0 |
|
SU555851A3 | |
| TRIAZOLYL-SUBSTITUTED COMPOUND OF TERTIARY AMINE AND PHARMACEUTICAL COMPOSITION | 1992 |
|
RU2124010C1 |
| METHOD FOR PREPARATION OF BENZOXAZEPINE COMPOUNDS | 2014 |
|
RU2649976C2 |
| DERIVATIVES OF TRIAZOLYLHYDRAZIDE AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS | 1990 |
|
RU2039051C1 |
| 0 |
|
SU520918A3 | |
| DERIVATIVES OF 1,2,4-TRIAZOLYLTHIOAMIDES | 1990 |
|
RU2045521C1 |
| DERIVATIVES OF 5-(AMINO-SUBSTITUTED)-1,2,4-TRIAZOLO-[1,5-A]-PYRIMIDINE, THEIR PHARMACEUTICALLY ACCEPTABLE ACID-ADDITIVE SALTS, PHARMACEUTICAL COMPOSITION SHOWING CARDIOTONIC AND CORONARY-DILATING ACTION AND A METHOD OF CARDIOTONIC AND/OR CORONARY-DILATING EFFECT ON HEART | 1992 |
|
RU2097382C1 |
