DERIVATIVES OF 1H-PYRAZOLO[4,3-c]ISOQUINOLINES, METHOD OF THEIR OBTAINING AND APPLICATION IN THERAPY Russian patent published in 2014 - IPC C07D471/04 A61K31/4745 A61P35/00

Abstract RU 2530775 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to compounds of formula (I)

in which R₁ stands for a phenyl group, optionally substituted with one or several halogen atoms; R₂ stands for hydrogen or a halogen atom or a cyanogroup; group -C(=O)Y, in which Y stands for a hydrogen atom or the group -NH₂ or -OR₃; group -C(=S)NH₂; group -C(=NH)NH-OH; group -CH₂OH or -CH₂F; group -CH=N-OH; group -CH=CH₂ or -C≡C-R_a; group (II) or (III); and R_a stands for the hydrogen atom or the (C₁-C₄)alkyl group; R₃ stands for thehydrogen atom or the (C₁-C₄)alkyl group; and R₄ stands for -NH₂, (C₁-C₄)alkyl, (C₁-C₄)fluoroalkyl or (C₃-C₇)cycloalkyl group. The invention also relates to methods of obtaining compounds of formula (I), a medical preparation, a pharmaceutical composition, intermediate compounds for obtaining the formula (I) compound and the application of the formula (I) compound and intermediate compounds.

EFFECT: claimed compounds have anti-cancer activity.

21 cl, 1 tbl, 28 ex

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RU 2 530 775 C2

Authors

Delettr Zhorzh

Depre Stefani

Alle Frank

Shio Loran

Tomson Fab'Enn

Dates

2014-10-10—Published

2010-04-22—Filed