FIELD: medicine.
SUBSTANCE: invention relates to compounds of formula I, or its stereomers, tautomers or pharmaceutically acceptable salts, where ring B and the NH-C(=X)-NH fragment are in trans configuration, and R1, R2, Ra, Rb, Rc, Rd, X, Ring B and Ring C are defined in the claims.
I.
EFFECT: compounds of formula I are inhibitors of TrkA kinase and are used to treat conditions such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis or pelvic pain syndrome.
19 cl, 2 tbl, 31 ex
| Title | Year | Author | Number |
|---|---|---|---|
| PYRROLIDINYL UREA AND PYRROLIDINYL THIOUREA COMPOUNDS AS TRKA KINASE INHIBITORS | 2012 |
|
RU2606131C2 |
| 1-((3S,4R)-4-(3-FLUOROPHENYL)-1-(2-METHOXYETHYL)PYRROLIDIN-3-YL)-3-(4-METHYL-3-(2-METHYLPYRIMIDIN-5-YL)-1-PHENYL-1N-PYRAZOL-5-YL)UREA AS A TRKA KINASE INHIBITOR | 2015 |
|
RU2719489C2 |
| SUBSTITUTED COMPOUNDS OF PYRAZOLE[1,5-a]PYRIMIDINE AS TRK KINASE INHIBITORS | 2010 |
|
RU2584157C2 |
| BICYCLIC UREA, THIOUREA, GUANIDINE AND CYANOHUANIDINE COMPOUNDS, USEFUL FOR THE TREATMENT OF PAIN | 2013 |
|
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| POINT MUTATIONS IN TRK INHIBITOR-RESISTANT MALIGNANT TUMORS AND RELATED METHODS | 2016 |
|
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| TRIAZOLOPYRINE COMPOUNDS AS KINASE INHIBITORS PIM | 2012 |
|
RU2598846C2 |
| SUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE COMPOUNDS AS INHIBITORS OF TRK KINASE | 2014 |
|
RU2666367C2 |
| SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS TROPOMYOSIN-RELATED KINASE INHIBITORS | 2009 |
|
RU2523544C2 |
| COMPOUNDS OF SUBSTITUTED N-(1H-INDAZOL-4-YL)IMIDAZOL [1,2-a]-3-CARBOXAMIDE AS cFMS INHIBITORS | 2010 |
|
RU2562977C2 |
| SUBSTITUTED N-(1H-INDAZOLE-4-YL) IMIDAZOLE [1,2-A]PYRIDINE-3- CARBOXAMIDE COMPOUNDS AS INHIBITORS OF TYROSINE KINASE TYPE III RECEPTOR | 2011 |
|
RU2591195C2 |
