AMIDE DERIVATIVES OF PYROSOL Russian patent published in 2018 - IPC C07D231/14 C07D231/56 C07D401/12 C07D401/14 C07D403/12 C07D405/12 C07D405/14 C07D409/12 C07D413/12 C07D417/12 C07D451/02 C07D471/04 C07D493/08 A61K31/415 A61K31/4155 A61K31/416 A61K31/427 A61K31/437 A61K31/4439 A61K31/46 A61K31/497 A61K31/501 A61K31/506 A61P11/06 A61P17/06 A61P19/02 A61P29/00 A61P37/02 

Abstract RU 2658827 C2

FIELD: pharmaceuticals.

SUBSTANCE: present invention relates to a novel compound, formula (I) or a pharmaceutically acceptable salt thereof that has the ability to suppress RORγ activity. In formula (I), the radicals and symbols have the meanings indicated in the claims. Present invention also relates to a pharmaceutical composition comprising said compound and a method of treating or preventing a disease using the compound (I).

EFFECT: new compound is proposed for the treatment or prevention of diseases such as multiple sclerosis, chronic rheumatoid arthritis, ankylosing spondylitis, systemic erythromatosis, psoriasis, psoriatic arthritis, inflammatory bowel disease or asthma.

12 cl, 8 tbl, 901 ex

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Authors

Bek Khilari Plejk

Buker Shon Kejt

Bregman Govard

Ki Viktor Dzh.

Chakka Nagashri

Kashing Timoti D.

Epstejn Oleg

Foks Brajan M.

Gens-Mejer Stefani

Khao Syaolin

Khibiya Kenta

Khirata Dzyun

Khua Chzhikhao

Khyuman Dzhejson

Kakuda Sindzi

Lopez Patrisiya

Nakadzima Reta

Okada Kadzukhisa

Olson Stiven Kh.

Oono Khiroyuki

Pennington Lyuis D.

Sasaki Kosuke

Simada Kejko

Sin Yunsok

Uajt Rajan D.

Vurts Rajan P.

I Syuyan

Chzhen Syao Mej

Dates

2018-06-25Published

2015-02-27Filed