METHOD FOR REDUCING BLOOD LOSS IN MAJOR JOINT REPLACEMENT UNDER GENERAL ANAESTHESIA Russian patent published in 2014 - IPC A61K31/15 A61K31/21 A61K31/132 A61K33/14 A61P7/00 

FIELD: medicine.

SUBSTANCE: haemodilution is performed with using crystalloid solutions, nitroglycerin and antihypertensive drugs. The antihypertensive drug is presented by using 5% pentamine intermittently administered after the beginning of the anaesthetic induction; if the effect of pentamine occurred to be inadequate, nitroglycerin is infused in an amount of 10 ml as a 0.1% solution diluted in crystalloid solution 200 ml for maintaining reference arterial blood pressure of 80/50 mm Hg. The nitroglycerin solution is kept to be administered until the wound is sutured, while the additional antihypertensive and blood loss reducing effect is ensured by spinal anaesthesia; as a haemostatic agent, an officinal solution of tranexamic acid 5-10 ml is intraoperatively intravenously introduced under an endoprosthesis bed.

EFFECT: lower risk of postoperative complications and ensured controlled stable arterial blood pressure in the patient.

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