METHOD OF OBTAINING ISOTHIAZOLE DERIVATIVE Russian patent published in 2014 - IPC C07D275/03

Abstract RU 2531273 C2

FIELD: chemistry.

SUBSTANCE: invention relates to a method of obtaining 3,4-dichloro-5-cyanoisothiazole, represented by general formula (3), which includes a reaction of a nitrile compound, represented by general formula (1), (where "n" stands for an integer number from 0 to 2), with sulphur chloride, represented by general formula (2): S_mCl₂ (2), (where "m" stands for an integer number from 0 to 2), or their mixture in an aprotic polar solvent. The aprotic polar solvent represents the aprotic polar solvent of an amide nature or a carbonate-ester nature. The nitrile compound of formula (1) in formed in a reaction of succinonitrile chlorination.

EFFECT: method of obtaining 3,4-dichloro-5-cyanoisothiazole, capable of ensuring the suppression of side formation of wastes without the application of highly toxic initial compounds; and at the same time capable of providing obtaining the product possessing a high degree of purity, with a high output and efficiency in industrial scale by a method, which is simple in realisation.

18 cl, 10 ex

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RU 2 531 273 C2

Authors

Nakamura Takajuki

Kumagai Khironobu

Ogava Makhito

Dates

2014-10-20—Published

2010-04-30—Filed