MODIFIED SACCHARIDES, THEIR CONJUGATES AND THEIR MANUFACTURE Russian patent published in 2014 - IPC C08B37/00

Abstract RU 2531909 C2

FIELD: biotechnologies.

SUBSTANCE: modified capsular saccharide includes linker of the following formula: -A-N(R¹)-L-M (I). With that, A represents -C(O)- or -OC(O)-. R¹ is chosen from H or C₁-C_6-alkyl. L represents group of C₁-C₁₂-alkene. M represents a masked aldehyde group. Besides, the invention proposes other versions of modified saccharide, versions of a saccharide modification method, a conjugate of saccharide-protein and a pharmaceutical composition. Preferably, a new linker is used to obtain saccharide conjugates Neisseria meningitidis of serogroup A.

EFFECT: invention allows obtaining conjugates with a new linker, which have improved immunising capacity.

10 cl, 3 dwg

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RU 2 531 909 C2

Authors

Dzhannotstsi Al'Do

Averani Dzhovanni

Norelli Franchesko

Kostantino Paolo

Dates

2014-10-27—Published

2008-12-19—Filed