FIELD: chemistry.
SUBSTANCE: capsular saccharides, obtained from serogroups W135 and Y Neisseria meningitidis, have changed levels of O-acetylation in positions 7 and 9 of their sialic acid residues. Modified meningococcal capsular saccharide of serogroup W135, where (a) ≤29% of sialic acid residues in saccharide are O-acetylated in position 7; and/or (b) ≥26% of sialic acid residues in saccharide are O-acetylated in position 9 and modified meningococcal capsular saccharide of serogroup Y, where a) <9% of sialic acid residues in saccharide are O-acetylated in position 7; and/or (b) ≥29% or ≤27% of sialic acid residues in saccharide are O-acetylated in position 9, can be used for creation of immunogenic compositions - compositions for inducing formation of antibodies in mammals and products of conjugation with carrier-proteins. Conjugates of derivatives demonstrate higher immunogenity in comparison to natural polysaccharides.
EFFECT: obtaining capsular saccharides which demonstrate higher immunogenity in comparison to natural polysaccharides.
29 cl, 6 dwg
