P38 KINASE-INHIBITING AGENTS Russian patent published in 2014 - IPC C07D417/12 C07D417/14 A61K31/427 A61K31/4439 A61K31/437 A61P11/06 A61P19/02 

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of general formula (I), possessing an activity with respect to cytokines, versions of based on them pharmaceutical compositions and their application. Formula (I) compounds can be applied for treatment or prevention asthma, COPD, ARDS, rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis or gouty arthritis. In general formula (I) L is selected from the group, consisting of -C(O)-, -CH₂-, Ar¹ represents a mono-, di- or trisubstituted phenyl ring, where substituents are independently selected from the group, consisting of a halogen and -C_1-4alkyl; Ar² represents an optionally substituted thiadiazolyl ring, where the substituent represents -C_1-4alkyl, -C_3-5cycloalkyl, -methylcyclopropyl, phenyl or a 5- or 6-membered monocyclic heteroaromatic ring or a bicyclic heteroaromatic ring with 9 or 10 atoms, with the said heteroaromatic ring containing 1, 2 or 3 heteroatoms, selected from the group, consisting of S, O and N, where the said phenyl or heteroaromatic ring is optionally mono- or disubstituted with substituents, independently selected from the group, consisting of a halogen, -C_1-6alkyl, optionally substituted with 1-4 fluorine atoms, -O-C_1-6alkyl, -CF₃ and oxo.

EFFECT: increased efficiency of the application of the compounds.

16 cl, 1 tbl, 46 ex