PREPARATION POSSESSING ANTITOXIC ACTIVITY AND CONTAINING COMPLEX COMPOUND, METHYLURACIL DERIVATIVE WITH ORGANIC ACID, AND METHOD FOR PREPARING IT Russian patent published in 2014 - IPC C07D239/60 C07D307/62 A61P39/02 

Abstract RU 2533423 C1

FIELD: medicine.

SUBSTANCE: preparation shows an antitoxic activity, and can be used as an antidote for nitrite and nitrate poisoning. A complex compound of 5-hydroxy-6-methyluracil with ascorbic acid (5-hydroxy-6-methyluracil ascorbate) is described by formula: The preparation contains the complex compound in an amount of 0.3-0.4 wt %, and ascorbic acid - the rest. The method for producing the preparation consists in a reaction of 5-hydroxy-6-methyluracil and ascorbic acid taken in the relation of ascorbic acid: 5-hydroxy-6-methyluracil equal to 1:(0.0015-0.0022), in water as a solvent at a temperature of 20-40°C for 30-60 minutes. The complex compound is produced as shown by infra-red and NMR spectra. The antitoxic activity of 5-hydroxy-6-methyluracil on nitrite has been unknown before.

EFFECT: water removal from the reaction mixture under low pressure.

2 cl, 2 tbl, 1 ex

Similar patents RU2533423C1

Title Year Author Number
COMPLEX COMPOUND OF 5-HYDROXY-1,3,6-TRIMETHYLURACYL WITH AMBIENT ACID, ANTIDITE ACTIVITY AND METHOD OF ITS PRODUCTION 2016
  • Myshkin Vladimir Aleksandrovich
  • Gimadieva Alfiya Raisovna
  • Repina Elvira Faridovna
  • Bakirov Akhat Barievich
  • Mustafin Akhat Gazizyanovich
  • Abdrakhmanov Ildus Barievich
RU2634731C1
ANTIHYPOXIC COMPLEX COMPOUND OF 5-HYDROXY-6-METHYLURACIL WITH ASCORBIC ACID AND METHOD FOR PRODUCING THEREOF 2016
RU2612517C1
A COMPLEX COMPOUND OF 5-HYDROXY-6-METHYLURACIL WITH n-ACETYLCYSTEINE, SHOWING ANTIHYPOXIC ACTIVITY, AND A METHOD FOR ITS PREPARATION 2020
  • Repina Elvira Faridovna
  • Gimadieva Alfiya Raisovna
  • Karimov Denis Olegovich
  • Kudoyarov Eldar Renatovich
  • Khusnutdinova Nadezhda Yurevna
  • Timasheva Gulnara Vilevna
  • Bajgildin Samat Sagadatovich
RU2751632C1
COMPLEX COMPOUND 1,3-BIS(2-HYDROXYETHYL)-5-HYDROXY-6-METHYLURACIL WITH FUMARIC ACID THAT EXHIBITS ANTI-HYPNOTIC ACTIVITY AND METHOD OF OBTAINING IT 2006
  • Krivonogov Viktor Petrovich
  • Myshkin Vladimir Aleksandrovich
  • Ibatullina Rifa Barievna
  • Abdrakhmanov Il'Dus Barievich
  • Mustafin Akhat Gaziz'Janovich
  • Bakirov Akhat Barievich
  • Gimadieva Al'Fija Raisovna
  • Chernyshenko Julija Nikolaevna
  • Savlukov Aleksandr Ivanovich
  • Srubilin Dmitrij Vital'Evich
RU2330025C2
COMPLEX OF 5-HYDROXY-6-METHYLURACIL WITH SODIUM SUCCINATE AND METHOD FOR PRODUCTION THEREOF 2012
  • Myshkin Vladimir Aleksandrovich
  • Repina Ehl'Vira Faridovna
  • Bakirov Akhat Barievich
  • Abdrakhmanov Il'Dus Barievich
  • Mustafin Akhat Gaziz'Janovich
  • Gimadieva Al'Fija Raisovna
RU2475482C1
COMPLEX COMPOUND OF 6-METHYLURACIL WITH SUCCINIC ACID ELICITING ANTIHYPOXIC ACTIVITY AND METHOD FOR ITS PREPARING 2003
  • Krivonogov V.P.
  • Myshkin V.A.
  • Ibatullina R.B.
  • Chernyshenko Ju.N.
  • Kozlova G.G.
  • Savlukov A.I.
  • Abdrakhmanov I.B.
  • Guljaeva I.L.
  • Myshkin I.V.
  • Sergeeva S.A.
RU2259357C2
METHYLURACIL DERIVATIVE AND ORGANIC ACID COMPLEX AND METHOD FOR PRODUCTION THEREOF 2013
  • Borisova Natal'Ja Sergeevna
  • Zimin Jurij Stepanovich
  • Gimadieva Al'Fija Raisovna
  • Mustafin Akhat Gaziz'Janovich
  • Larionov Sergej Leonidovich
  • Safarova Irina Vladimirovna
RU2543375C1
AGENT REPRESENTING 5-AMINO-6-METHYLURACIL AND EXHIBITING ANTIOXIDANT ACTIVITY AND METHOD FOR PREPARING THEREOF 2008
  • Mustafin Akhat Gaziz'Janovich
  • Gimadieva Al'Fija Raisovna
  • Chernyshenko Julija Nikolaevna
  • Abdrakhmanov Il'Dus Barievich
  • Myshkin Vladimir Aleksandrovich
  • Ibatullina Rifa Barievna
RU2398767C2
COMPLEX CONNECTION OF 5-HYDROXY-3,6-DIMETHYLURACYL WITH SUCCINIC ACID EXHIBITING MEMBRANE-STABILIZING ACTIVITY AND METHOD OF ITS PRODUCTION 2016
  • Myshkin Vladimir Aleksandrovich
  • Repina Elvira Faridovna
  • Bakirov Akhat Barievich
  • Gimadieva Alfiya Raisovna
  • Karimov Denis Olegovich
  • Khusnutdinova Nadezhda Yurevna
RU2631238C1
COMPLEX COMPOUND OF 5-AMINOSALICYLIC ACID WITH OXIDISED PECTIN, EXHIBITING ANTIULCER ACTIVITY, AND METHOD FOR PRODUCTION THEREOF 2023
  • Kutlugildina Galiia Gaiazovna
  • Zimin Iurii Stepanovich
  • Gimadieva Alfiia Raisovna
  • Karimov Denis Olegovich
  • Khusnutdinova Nadezhda Iurevna
  • Repina Elvira Faridovna
RU2818489C1

RU 2 533 423 C1

Authors

Gerchikov Anatolij Jakovlevich

Safarova Irina Vladimirovna

Abdrakhmanov Il'Dus Barievich

Myshkin Vladimir Aleksandrovich

Ibatullina Rifa Barievna

Savlukov Aleksandr Ivanovich

Zimin Jurij Stepanovich

Borisova Natal'Ja Sergeevna

Dates

2014-11-20Published

2013-05-14Filed