FIELD: chemistry.
SUBSTANCE: claimed invention relates to a method of obtaining a chelate compound of metal or its salt, used as a diagnostic reagent. The method includes the following stages: a) contact of a liquid composition, containing a metal ion, with a cation-exchange solid carrier, modified by functional groups of iminodiacetic acid or thiourea, to obtain a metal-chelate carrier; and b) contact of the said metal-chelate carrier with a liquid composition, containing an aminocarboxylic chelating reagent or its salt. The said metal in the chelate compound or ion component represents a lanthanide. Also claimed is a method of obtaining gadobenate dimeglumine.
EFFECT: method makes it possible to selectively obtain the chelate metal compound with the high output in the form, which in fact does not contain by-products or a material that has not reacted.
11 cl, 3 ex
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Authors
Dates
2014-11-20—Published
2010-12-15—Filed