ANTIDEPRESSANT Russian patent published in 2014 - IPC A61K31/221 A61K31/165 A61P25/24 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to medicine, namely to pharmacology, and deals with a synthetic biologically active compound - hydrochloride of 2-(diethylamino)ethyl ether of 9-hydroxy-9H-fluorene carboxylic acid, representing an amyzilum M-cholinoblocker derivative. The said amyzilum derivative has not been described before. The claimed compound possesses low toxicity, its synthesis is simple and available. It is demonstrated that hydrochloride of 2-(diethylamino)ethyl ether of 9-hydroxy-9H-fluorene carboxylic acid, representing the amyzilum M-cholinoblocker derivative demonstrates an expressed antidepressant activity and an anxiolytic action, possesses a sedative, and in high doses a soporific effect, it also positively influences an exploratory ability and memory. In addition, it has been stated that the claimed pharmacological substance in expressiveness of the antidepressant properties surpasses the widely applied tricyclic antidepressant amitriptylinum. The obtained data make it possible to recommend the claimed amyzilum derivative as the antidepressant for the treatment of depression and anxiety disorders.

EFFECT: invention extends an arsenal of pharmacological means, used as depression therapy.

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