SUSPENSION AND HARDENED COMPOSITION CONTAINING CARBOSTYRIL DERIVATIVE AND SILICONE OIL AND/OR SILICONE OIL DERIVATIVE Russian patent published in 2014 - IPC A61K9/10 A61K31/4704 A61K47/44 A61P25/18 

FIELD: chemistry.

SUBSTANCE: invention discloses a method of preventing agglomeration of particles of an aripiprazole or 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butox]-1H-quinolin-2-one active ingredient in a suspension containing silicone oil and/or a silicone oil derivative in a dispersion medium, wherein the particle size of the active ingredient is 0.1-200 mcm. The method comprises mixing an active ingredient with silicone oil and/or silicone oil derivative in a dispersion medium such that the silicone oil and/or silicone oil derivative is contained in an amount of 0.001-0.2 pts.wt per 100 pts.wt of the active ingredient contained in the suspension. The invention also relates to a hardened composition for preparing a suspension administered by injection or orally.

EFFECT: preventing agglomeration of active ingredients in a suspension without special treatment.

9 cl, 4 tbl, 9 ex