METHOD OF PURIFYING CYCLOPOLYPEPTIDE COMPOUNDS OR SALTS THEREOF Russian patent published in 2014 - IPC C07K1/22 C07K7/56 

FIELD: chemistry.

SUBSTANCE: method includes steps of: (1) feeding a raw compound of formula I into a macroporous adsorption resin; (2) washing the macroporous adsorption resin with water, an organic solvent or a mixed solution of an organic solvent and water as the washing liquid; and (3) elution of the compound of formula I from the macroporous adsorption resin with water, an organic solvent or a mixed solution of an organic solvent and water as an eluent, where at step (1) the solution containing a raw compound of formula I contains ionisable salts; and the macroporous adsorption resin is selected from a nonpolar aromatic adsorption resin polymerised from styrene and divinyl benzene, or a methacrylic adsorption resin of medium polarity with methacrylate residues in the structure.

EFFECT: purification method has the advantages of using a small amount of organic solvents without using silica gel and low environmental impact; the collected compound also has better purity compared to previous methods.

13 cl, 2 tbl, 2 dwg, 8 ex