HIGH PURITY CYCLOPEPTIDE COMPOUND AS WELL AS PREPARATION METHOD AND USE THEREOF Russian patent published in 2016 - IPC C07K7/56 C07K1/30 A61K38/12 A61P31/10 

FIELD: chemistry.

SUBSTANCE: invention relates to a method of producing a cyclopeptide compound of formula I with high purity, where R is H or a cation capable of forming a pharmaceutically acceptable salt. Method comprises (a) dissolving a compound of formula I in water or aqueous organic solvent (i) and controlling pH of solution; and (b) obtaining cyclopeptide compound of formula I with high purity by lowering temperature and/or adding an organic solvent (i), where at step (a) pH of solution is maintained at a level of 2.0 to 5.9; and at step (a) or (b) said organic solvent (i) is selected from C1-C4 lower alcohol.

EFFECT: method enables to obtain a compound of formula I, purity of which higher than or equal to 99 %.

5 cl, 6 dwg, 31 tbl, 24 ex