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(19)

(11)

2 595 718

(13)

(51)

IPC

C12N9/12(2006-01-01)

A61K47/48(2006-01-01)

C07D401/14(2006-01-01)

C07D401/04(2006-01-01)

C07D417/06(2006-01-01)

A61K31/496(2006-01-01)

A61K31/506(2006-01-01)

A61K31/4709(2006-01-01)

A61K31/519(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2012110024/04, 2010-09-09

(24)

Start date

2010-09-09

(22)

Actual filing date

2010-09-09

(45)

Published

2016-08-27

(72)

Inventor

Nyu DetsyanPetter Rassel S.Singkh DzhasvinderKlyug Artur F.Mazdiyasni KhormozChzhu ChzhendonTsyao LisinKuntts Kevin

(73)

Holder

Seldzhen Avilomiks Riserch,Ink.

PI3-KINASE INHIBITORS AND USE THEREOF Russian patent published in 2016 - IPC C12N9/12 A61K47/48 C07D401/14 C07D401/04 C07D417/06 A61K31/496 A61K31/506 A61K31/4709 A61K31/519 A61P35/00

Abstract RU 2595718 C2

FIELD: pharmaceutics.

SUBSTANCE: invention relates to compounds which are irreversible PI3-kinase inhibitors, and conjugates containing one or more PI3-kinases, containing cysteine residue, which is covalently and irreversibly boned with PI3-kinase inhibitor. Invention also discloses pharmaceutical compositions containing said compounds.

EFFECT: compounds are intended for treating disorders and diseases associated with PI3-kinase.

19 cl, 16 dwg, 26 tbl, 52 ex

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RU 2 595 718 C2

Authors

Nyu Detsyan

Petter Rassel S.

Singkh Dzhasvinder

Klyug Artur F.

Mazdiyasni Khormoz

Chzhu Chzhendon

Tsyao Lisin

Kuntts Kevin

Dates

2016-08-27—Published

2010-09-09—Filed