AMORPHOUS (5-FLUORO-2-METHYL-3-QUINOLIN-2-YLMETHYLINDOL-1-YL)-ACETIC ACID Russian patent published in 2017 - IPC C07D401/06 A61K31/4709 A61P11/00 A61P11/06 A61P1/04 A61P17/00 A61P31/00 A61P37/00

Abstract RU 2616000 C2

FIELD: chemistry.

SUBSTANCE: invention relates to organic chemistry, specifically to a stable solid dispersion (5-fluoro-2-methyl-3-quinolin-2-ylmethylindol-1-yl)-acetic acid (Compounds 1), containing amorphous (5-fluoro-2-methyl-3-quinolin-2-ylmethylindol-1-yl)-acetic acid (Compound 1) or its pharmaceutically or veterinarily acceptable salt and polymer, selected from polyvinylpyrrolidone (PVP), polyvinylpyrrolidone-vinyl acetate copolymer (PVP-VA), hydroxypropyl methylcellulose (HPMC) and hypromellose acetate succinate (HPMC AS) and their mixtures. Invention also relates to a method of producing said stable solid dispersion, its application, method of treating said diseases and pharmaceutical composition based on stable solid dispersion.

EFFECT: obtaining a stable solid dispersion based on amorphous compound 1 and polymer, useful for treating or preventing diseases mediated by prostaglandin D₂ (PGD₂) or other agonists, acting on CRTH2 receptor.

22 cl, 17 dwg, 15 tbl, 13 ex

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RU 2 616 000 C2

Authors

Betankur Ajmester

Lemyu Mark

Tibert Rosh

Dates

2017-04-12—Published

2012-02-14—Filed