FIELD: chemistry.
SUBSTANCE: invention relates to improved method of obtaining 2-chloro-5-hydroxymethylpyridine, which includes activation of carboxyl group of 6-chloronicotinic acid and reduction of 6-chloronicotinoylchloride. Method is characterised by the fact that reaction of carboxyl group activation is carried out with cyanuric chloride at temperature of reaction mixture 20°C in presence of N-methylmorpholine, with application of dimethoxyethane as solvent, and reduction of activated ester is realised with sodium borohydride solution in water for 10 minutes. Obtained compound is applied in organic synthesis of biologically active substances, modelling activity of proteinkinases and yohimbine alkaloids.
EFFECT: obtaining 2-chloro-5-hydroxymethylpyridine with high output, increased safety of process, activation of carboxyl group is realised at low temperature of reaction mixture, with reducing time for activated ester reduction to 10 minutes.
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