FIELD: organic chemistry, amino acids, chemical technology.
SUBSTANCE: invention relates to a new method for preparing novel derivatives of phenylalanine. Also, invention relates to new compounds used as intermediate substances used in this method. Invention proposes a method for synthesis of compounds of the formula (I) 
wherein X1 means halogen atom; X2 means halogen atom; Q means group of the formula -CH2- or -(CH2)2-; Y represents lower alkyl group, or its pharmaceutically acceptable salt that shows the excellent inhibitory effect against cellular adhesion mediated with integrin α4, and a semi-finished product used in this method. Proposed method provides the possibility for preparing compound of the formula (I) or its pharmaceutically acceptable salt of the high purity in combination with the high yield and small consumptions.
EFFECT: improved preparing method.
13 cl, 8 ex
| Title | Year | Author | Number |
|---|---|---|---|
| ALPHA4-INTEGRINE MEDIATED CELL ADHESION INHIBITORS | 2001 |
|
RU2250895C2 |
| METHOD OF PRODUCING BENZO[b]THIOPHENE COMPOUND | 2012 |
|
RU2601420C2 |
| PYRIDINE DERIVATIVES, PROCESS FOR PREPARATION THEREOF, INSECTICIDAL COMPOSITION | 1993 |
|
RU2083562C1 |
| SACCHARIN DERIVATIVES OR THEIR PHARMACEUTICALLY ACCEPTABLE ACID OR BASE ADDITIVE SALT, PHARMACEUTICAL COMPOSITION EXHIBITING ACTIVITY OF ELASTASE INHIBITOR | 1992 |
|
RU2114835C1 |
| 5-HYDROXYPYRIMIDINE-4-CARBOXAMIDE DERIVATIVE | 2010 |
|
RU2550693C2 |
| DERIVATIVES OF BENZOTHIAZINE DIOXIDE, PHARMACEUTICAL COMPOSITION BASED ON THEREOF SHOWING INHIBITORY ACTIVITY OF ENDOTHELIN RECEPTOR AND METHOD OF INHIBITION OF ENDOTHELIN RECEPTOR | 1996 |
|
RU2164225C2 |
| NOVEL 2,4-DIAMINOTHIAZOL-5-ONE DERIVATIVES | 2005 |
|
RU2395501C2 |
| SULFONAMIDE DERIVATIVE AND MEDICINAL USE THEREOF | 2013 |
|
RU2607081C2 |
| HERBICIDE AGENT BASED ON ARYLSULFONYLAMINOCARBONYLTRIAZOLINONES | 1997 |
|
RU2240691C2 |
| SUBSTITUTED AMIDE COMPOUNDS | 2010 |
|
RU2563639C2 |
