TABLETTED MULTIUNIT DOSAGE, METHOD OF ITS OBTAINING AND METHOD FOR INHIBITING GASTRIC ACID SECRETION OR TREATING GASTROINTESTINAL DISEASES IN MAMMALS AND HUMANS Russian patent published in 2015 - IPC A61K9/20 A61K31/4184 A61P1/04 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to a tabletted multiunit dosage form containing an active substance specified in a compound of N⁺K⁺ATPhase inhibitor, one its individual enantiomer and its alkaline salt, wherein individually enteric-coated units of a nuclear material containing the active substance optionally mixed with alkaline compounds, is mixed with tablet excipients and tabletted. The enteric coating is at least 10 mcm thick and has such mechanical properties that tabletting the individual units mixed with the excipients in the multiunit tabletted dosage form does not reduce the acid stability of the enteric coated units by more than 10%. The invention also refers to a method for preparing the multiunit dosage form, according to which the material units containing the active substance are mixed whenever necessary with the alkaline compounds; then these can be coated with separate layers; the enteric coating is applied, mixed with the excipients and tabletted.

EFFECT: what is declared is a method for inhibiting gastric acid secretion or treating gastrointestinal diseases in mammals and humans by administering a therapeutically effective dose of the multiunit tabletted dosage form.

17 cl, 2 tbl, 19 ex