COMBINATION OF PHOSPHATIDYL INOSITOL-3-KINASE (PI3K) INHIBITOR AND mTOR INHIBITOR Russian patent published in 2015 - IPC A61K31/5377 A61K31/506 A61K31/444 A61K31/436 A61P35/00 

Abstract RU 2538683 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: what is presented is a group of inventions concerning treating and preventing a disease dependent on mTOR (mammalian target of rapamycin) kinase and representing cancer or malignant growth. The group involves a pharmaceutical combination for the above application containing 5-(2,6-dimorpholin-4-ylpyrimidin-4-yl)-4 trifluoromethylpyridin-2-ylamine or its salt and the mTOR inhibitor everolimus; using it for preparing a drug preparation for the same application and a pharmaceutical composition containing the above combination.

EFFECT: synergetic effect of the antitumour action of 5-(2,6-dimorpholin-4-ylpyrimidin-4-yl)-4 trifluoromethylpyridin-2-ylamine and everolimus.

7 cl, 2 dwg

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RU 2 538 683 C2

Authors

Karlos Garsija-Ehcheverrija

Sove-Mishel' Maira

Dates

2015-01-10Published

2009-10-29Filed