MORPHOLINO-SUBSTITUTED DERIVATIVES OF UREA OR CARBAMATE AS MTOR INHIBITORS Russian patent published in 2017 - IPC C07D251/22 C07D401/12 C07D407/12 C07D413/04 A61K31/53 A61P37/00 A61P35/00 

FIELD: pharmacology.

SUBSTANCE: invention relates to compounds of formula (I) , where m equals 1 or 2; n equals 0, 1 or 2; each of R¹ is independenly selected from the group consisting of C_1-6alkyl, where C_1-6alkyl is probably substitued with one R³; probably, two R¹ are joint with a ring to which they are attached to form 8-membered heterobicycle; R³ is OR⁴; R⁴ is H; T⁰ is phenyl where T⁰ is substituted with the group N (R^5a) C(O) N (R^5bR⁵); R^5a, R^5b are independently selected from the group consisting of H; R⁵ is T² or C_1-6alkyl, where C_1-6alkyl is probably substituted with 1-4 R⁸, which are the same or different; R⁸ is halogen; OR⁹; N (R⁹R^9a); R⁹, R^9a are independently selected from the group consisting of H; T² is C_3-7cycloalkyl; 4-6-membered heterocyclyl, wherein 1 circular atom is substituted with oxygen heteroatom; 6-membered aromatic heterocyclyl, wherein 1 circular atom is substituted with nitrogen heteroatom; and phenyl, wherein T² is probably substituted with one or two R¹⁰, which are the same or different; R¹⁰ is halogen; OR¹¹; or C_1-6alkyl, where C_1-6alkyl is probably substituted with one R¹²; R¹¹ is H; R¹² is OR¹³; R¹³ is H; T¹ is phenyl or 6-membered aromatic heterocycle, wherein 1 carbon atom is substituted with nitrogen heteroatom, wherein T¹ is substituted with a group S(O)₂R¹⁴ and is probably additionally substituted with one R¹⁵; R¹⁵ is halogen; R¹⁴ is C_1-6alkyl or unsubstituted 5-membered heterocyclyl ring, wherein 1 circular atom is substituted with nitrogen heteroatom. Compounds of formula (I) possess mTOR inhibitory activity. The invention also relates to a pharmaceutical composition, to compound application for drug manufacture and to a treatment method.

EFFECT: new compounds of formula are obtained, which are useful for treatment or prevention of mTOR-related diseases and disorders.

21 cl, 6 tbl, 44 ex