METHOD FOR CEPHALOSPORIN BIOENCAPSULATION Russian patent published in 2015 - IPC A61K9/50 A61K31/545 A61K47/42 A61J3/07 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to microencapsulation, particularly to a method for cephalosporin microencapsulation. The method is characterised by the fact that a microcapsule coating is human serum albumin; a powder cephalosporin preparation is added to an aqueous solution in the presence of a surfactant; a ratio of the powder cephalosporin preparation to albumin at a dry substance matter makes 1:1 to 3:1; the prepared mixture is agitated, methylcarbinol is added as a first precipitator, and then isopropanol is added as a second precipitator; the prepared suspension of microcapsules is filtered, washed in isopropanol, dried in an exiccator; the process of microcapsules is performed at 25°C.

EFFECT: method provides simplifying and accelerating the process of microcapsules of water-soluble cephalosporin preparations in serum albumin, reducing the loss accompanying the process of microcapsules (higher weight yield).

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