METHOD FOR CEPHALOSPORIN BIOENCAPSULATION Russian patent published in 2015 - IPC A61K9/50 A61K31/545 A61K47/42 A61J3/07 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to microencapsulation, particularly to a method for cephalosporin microencapsulation. The method is characterised by the fact that a microcapsule coating is human serum albumin; an aqueous solution of albumin is added with the cephalosporin powder in the presence of a surfactant; the ratio of the cephalosporin preparation to albumin in terms of dry substance makes from 1:1 to 3:1; the prepared mixture is stirred and added with isopropanol as the first precipitation agent, and then acetone as the second precipitation agent; the prepared microcapsule suspension is filtered, washed in acetone, dried in a drying cabinet; the microencapsulation process is performed at 25°C.

EFFECT: method provides simplifying and fastening the microencapsulation process of water-soluble cephalosporins in serum albumin, reducing the loss accompanying the microencapsulation process.

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