METHOD OF BIOENCAPSULATION OF CEPHALOSPORIN GROUP MEDICATIONS Russian patent published in 2015 - IPC A61K9/50 A61K31/545 A61K47/42 A61J3/07 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to the field of microencapsulation, in particular to a method of obtaining microcapsules of medications of a cephalosporin group. The method is characterised by the fact that human serum albumin is used as an envelope for microcapsules, with the addition to a water solution of albumin of a powder of a cephalosporin group preparation in the presence of a surface-active substance E472c, the ratio of quantity of the cephalosporin group preparation to albumin counted per dry substance constitutes from 1:1 to 3:1, the obtained mixture is mixed to the complete dissolution of components with the slow drop-by-drop addition of butanol as the first precipitating agent, and then acetone as the second precipitating agent, the obtained suspension of microcapsules is filtered, washed with acetone, dried in a dessicator, the process of obtaining microcapsules is realised at 25°C.

EFFECT: method provides the simplification and acceleration of the process of obtaining microcapsules of the water-soluble medications of a cephalosporin group in human serum albumin, and reduction of loss in obtaining the microcapsules.

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