NEW PHENOL DERIVATIVES AND THEIR PHARMACEUTICAL OR COSMETIC APPLICATION Russian patent published in 2015 - IPC C07D213/74 C07D239/42 C07D241/20 A61K31/44 A61K31/505 A61K31/4965 A61K8/49 A61Q5/00 A61Q19/00 A61P17/00 A61P15/00

Abstract RU 2540858 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to compounds of structural formula (I), which can be used for treating diseases mediated by an androgen receptor. In formula (I), R₁ means (C_2-6)alkyl, (C_1-6)alkyloxy, -S(O)_m-(C_1-6)alkyl, (C_1-6)fluoroalkyl, CN or halogen, R₂ and R₃ are identical or different and mean a hydrogen atom or (C_1-9)alkyl, R₄, R₅, R₆, R₇ are identical or different and mean a hydrogen or halogen, X means CH or N, Y means either a nitrogen atom, or a carbon atom substituted by (C_1-6)alkyl, (C_1-6)alkyloxy, (C_1-6)fluoroalkyl, a hydrogen atom or halogen; m is equal to 0, 1 or 2.

EFFECT: invention refers to using the compounds for preparing a therapeutic agent for preventing and/or treating hirsutism, androgenetic alopecia, hypertrichosis, atopic dermatitis, disordered sebaceous gland, such as hyperseborrhea, acne, greasy skin or seborrheic dermatitis.

8 cl, 2 tbl, 26 ex

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RU 2 540 858 C2

Authors

Puansar Sedrik

Kollett Paskal'

Moveh Paskal'

Lehnzhe Zhan-Mishel'

Retore Sandrin

Dates

2015-02-10—Published

2010-12-22—Filed