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(19)

RU

(11)

2 540 858

(13)

C2

(51)

IPC

C07D213/74(2006-01-01)

C07D239/42(2006-01-01)

C07D241/20(2006-01-01)

A61K31/44(2006-01-01)

A61K31/505(2006-01-01)

A61K31/4965(2006-01-01)

A61K8/49(2006-01-01)

A61Q5/00(2006-01-01)

A61Q19/00(2006-01-01)

A61P17/00(2006-01-01)

A61P15/00(2006-01-01)

(21) (22)

Application

2012130958/04, 2010-12-22

(24)

Start date

2010-12-22

(22)

Actual filing date

2010-12-22

(45)

Published

2015-02-10

(72)

Inventor

Puansar SedrikKollett Paskal'Moveh Paskal'Lehnzhe Zhan-Mishel'Retore Sandrin

(73)

Holder

Galderma Reserch Ehnd Development

NEW PHENOL DERIVATIVES AND THEIR PHARMACEUTICAL OR COSMETIC APPLICATION Russian patent published in 2015 - IPC C07D213/74 C07D239/42 C07D241/20 A61K31/44 A61K31/505 A61K31/4965 A61K8/49 A61Q5/00 A61Q19/00 A61P17/00 A61P15/00 

Abstract RU 2540858 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to compounds of structural formula (I), which can be used for treating diseases mediated by an androgen receptor. In formula (I), R1 means (C2-6)alkyl, (C1-6)alkyloxy, -S(O)m-(C1-6)alkyl, (C1-6)fluoroalkyl, CN or halogen, R2 and R3 are identical or different and mean a hydrogen atom or (C1-9)alkyl, R4, R5, R6, R7 are identical or different and mean a hydrogen or halogen, X means CH or N, Y means either a nitrogen atom, or a carbon atom substituted by (C1-6)alkyl, (C1-6)alkyloxy, (C1-6)fluoroalkyl, a hydrogen atom or halogen; m is equal to 0, 1 or 2.

EFFECT: invention refers to using the compounds for preparing a therapeutic agent for preventing and/or treating hirsutism, androgenetic alopecia, hypertrichosis, atopic dermatitis, disordered sebaceous gland, such as hyperseborrhea, acne, greasy skin or seborrheic dermatitis.

8 cl, 2 tbl, 26 ex

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RU 2 540 858 C2

Authors

Puansar Sedrik

Kollett Paskal'

Moveh Paskal'

Lehnzhe Zhan-Mishel'

Retore Sandrin

Dates

2015-02-10—Published

2010-12-22—Filed

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