ANTIVIRAL COMPOUND Russian patent published in 2012 - IPC C07D495/04 C07D471/04 C07D513/04 A61K31/519 A61P31/12 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to new compounds or their pharmaceutically acceptable salts where the compound has formula (I). The compounds have the properties of hepatitis C virus (HCV) replication inhibition and can be used for treating HCV-infection. In formula (I) B represents heterocyclyl selected from thieno, thiazolo, pyrazolo, pyrido and pyrimidogroup with B being optionally substituted by one or more R¹⁸, A represents phenyl which is optionally substituted by one or more R¹⁸; each W₁ and W₂ are independently selected from N or C(R³³); Z represents -NH-; each R¹⁰ and R³³ containing of hydrogen; X is selected from a group consisting of -L_s-O-, -L_s-S-; R²² means hydrogen or phenyl optionally substituted by one or more R²⁶ ; Y is selected from a group consisting of -L_s-O-, -L_s-S-_; -L_s-C(O)- and -L_s-NH(SO)₂-; R⁵⁰ represents -L¹-A¹, where L¹ represents a bond, and A¹ is selected from a group consisting of carbocyclyl where carbocyclyl represents phenyl or C₃-C₆carbocyclyl, banzimidazolyl and C₁-C₆alkyl optionally substituted by phenyl where A¹ is optionally substituted by one or more R³⁰ ; the substitute values are specified in the patent claim.

EFFECT: preparing the compounds exhibiting the properties of hepatitis C virus replication inhibition.

17 cl, 8 dwg, 255 ex