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(19)

RU

(11)

2 571 662

(13)

C2

(51)

IPC

C07C15/58(2006-01-01)

C07D239/54(2006-01-01)

C07D409/10(2006-01-01)

C07D213/64(2006-01-01)

C07D207/27(2006-01-01)

C07D233/32(2006-01-01)

C07D275/02(2006-01-01)

C07D239/10(2006-01-01)

C07D405/10(2006-01-01)

C07D403/10(2006-01-01)

A61K31/513(2006-01-01)

A61K31/4412(2006-01-01)

A61P31/14(2006-01-01)

(21) (22)

Application

2011142978/04, 2010-03-25

(24)

Start date

2010-03-25

(22)

Actual filing date

2010-03-25

(45)

Published

2015-12-20

(72)

Inventor

Betebenner Dehvid A.Pratt Dzhon K.Degoj Dehvid A.Donner Pamela L.Flentge Charl'Z A.Khatchinson Duglas K.Kati Uorren M.Krjuger Allan K.Longeneker Kenton L.Maring Klarens Dzh.Randolf Dzhon T.Rokuehj Todd V.T'Jufano Majkl D.Vagner Rol'FLju Dachun'

(73)

Holder

Ehbbvi Ink.

ANTIRETROVIRAL COMPOUNDS AND USE THEREOF Russian patent published in 2015 - IPC C07C15/58 C07D239/54 C07D409/10 C07D213/64 C07D207/27 C07D233/32 C07D275/02 C07D239/10 C07D405/10 C07D403/10 A61K31/513 A61K31/4412 A61P31/14 

Abstract RU 2571662 C2

FIELD: medicine.

SUBSTANCE: invention refers to new compounds of formula (I) and their pharmaceutically acceptable salts, which inter alia inhibit hepatotropic hepatitis C virus and are applicable in treating hepatitis C virus. In formula (I) R1 is specified in a group consisting of

is specified in a group consisting of a carbon-carbon single bond and carbon-carbon double bond; R5, R6, R11, R12, R13 and R14 are independently specified in a group consisting of a hydrogen atom, methyl and a protective group for nitrogen specified in C1-6alkylsulphonyl; R7 represents a hydrogen atom; R2 is specified in a group consisting of a halogen atom, C1-6alkyl and heterocyclyl specified in 5-merous heteroaryl with 1-2 heteroatoms specified in nitrogen, oxygen and sulphur, wherein alkyl is optionally substituted by one or more substitute optionally specified in a group consisting of a halogen atom; and heterocyclyl is optionally substituted by C1-3alkyl; R3 is specified in a group consisting of C1-6alkyl, C2-4alkenyl, C1-6alkyloxy and a halogen atom; L means a bond, and R4 is specified in a group consisting of C5-C6-carbocyclyl, or R4 means carbocyclyl with 2 condensed cycles specified in a group consisting of naphthalinyl, indenyl and dihydroindenyl, hexahydroindenyl, octahydroindenyl, wherein each can be substituted by a substitute specified in a group consisting of RE, RF and RJ, and RE means hydroxy, oxo; RF means C1-3alkyl substituted by C1-4alkylsulphonylamino, imino, wherein imino is substituted by a C1-4alkylsulphonylamino group; and RJ means an alkylsulphonylamino group; or L is specified in a group consisting of C(RA) = C(RB), wherein RA and RB mean a hydrogen atom, and R4 is specified in a group consisting of C6carbocyclyl specified in phenyl substituted by RJ having the above value.

EFFECT: higher efficacy of the compound.

16 cl, 2 tbl, 52 ex

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RU 2 571 662 C2

Authors

Betebenner Dehvid A.

Pratt Dzhon K.

Degoj Dehvid A.

Donner Pamela L.

Flentge Charl'Z A.

Khatchinson Duglas K.

Kati Uorren M.

Krjuger Allan K.

Longeneker Kenton L.

Maring Klarens Dzh.

Randolf Dzhon T.

Rokuehj Todd V.

T'Jufano Majkl D.

Vagner Rol'F

Lju Dachun'

Dates

2015-12-20—Published

2010-03-25—Filed

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