METHOD OF TREATING PROSTATE CANCER WITH USING PROLONGED PRODRUG OF OCTREOTIDE ACCOMPANYING SURGICAL OR DRUG-INDUCED CASTRATION Russian patent published in 2015 - IPC G01N33/49 A61K35/00 

Abstract RU 2541810 C2

FIELD: medicine.

SUBSTANCE: invention refers to medicine, particularly to oncourology, and can be used in the non-surgical treatment of the patients suffering early stages of prostate malignant tumour. A method of treating prostate cancer with using prolonged prodrug of octreotide accompanying surgical or drug-induced castration involves a) measuring pre-therapeutic prostate-specific antigen; b) measuring pre-therapeutic blood plasma chromogranin A; c) selecting the patients having high blood chromogranin A of more than 3 nmol/l; d) conducting a therapy with prolonged prodrug of octreotide in a combination with dexamethasone in the selected patients; e) controlling the prostate-specific antigen variation every month and monitoring a decrease thereof in the patients by measuring it intra-therapeutically according to the stage d); the therapeutic efficacy according to the stage d) is evaluated by a therapeutic response, which is accompanied by maximum decrease of the prostate-specific antigen.

EFFECT: invention enables providing the higher therapeutic efficacy in the patients suffering prostate cancer at the different stages.

3 cl, 1 tbl, 5 ex

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Authors

Nazarenko Anna Borisovna

Apolikhin Oleg Ivanovich

Sivkov Andrej Vladimirovich

Efremov Gennadij Dmitrievich

Rabinovich Ehduard Zinov'Evich

Keshishev Nikolaj Georgievich

Kovchenko Grigorij Aleksandrovich

Prokhorov Sergej Arkad'Evich

Sokov Dmitrij Gennad'Evich

Nikonova Larisa Marbekovna

Dates

2015-02-20Published

2013-05-23Filed