METHOD OF OBTAINING PROPIONIC ACID DERIVATIVES Russian patent published in 2015 - IPC C07D413/12 C07F17/02 C07F9/28 B01J31/22 

Abstract RU 2544989 C2

FIELD: chemistry.

SUBSTANCE: invention relates to a method of obtaining (S)-2-methoxy-3-{4[2-(5-methyl-2-phenyloxazol-4-yl)ethoxy]benzo[b]thiophen-7-yl}propionic acid of formula (I) or its salts, in which formula (II) compound or its salt is hydrated in the presence of an iridium-including catalyst, in which the catalyst includes iridium and formula (III) compound, in which R1 stands for hydrogen, isopropyl, phenyl or benzyl and in which R2 stands for phenyl, 3,5-dimethylphenyl or 3,5-di-tert-butylphenyl. The invention also relates to the application of a complex of the catalyst, containing iridium and the formula (III) compound for obtaining the formula (I) compound.

EFFECT: obtaining the formula (I) compound with a high degree of conversion and enantiomeric purity.

6 cl, 4 tbl, 21 ex

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RU 2 544 989 C2

Authors

Kurt Pjuntener

Mikelandzhelo Skalone

Dates

2015-03-20Published

2010-03-19Filed