METHOD OF ENANTIOSELECTIVE SYNTHESIS OF OPTICALLY ACTIVE SUBSTITUTED DERIVATIVES OF 5,6-DIHYDRO-2H-PYRANE-2-ONE Russian patent published in 1999 - IPC

FIELD: organic chemistry and technology. SUBSTANCE: invention relates to a new catalytic method of synthesis of optically active compounds of the general formula (I) where R¹ and R² mean alkyl that can be broken by oxygen atom at position that is different of α- or β-position, or optionally substituted benzyl; R³ means hydrogen, lower alkyl, optionally substituted benzyl, -CO-R⁴, -COO-R⁴ or -CON-R42

where R⁴ means lower alkyl or aryl. Compounds are synthesized by asymmetric hydrogenation of compound of the formula (II) where R¹,R²,R³ have values indicated above. Compounds are subjected for asymmetric hydrogenation in the presence of a complex of optically active, preferably atropoisomeric diphosphine ligand, with metal of group VIII. EFFECT: improved and simplified method of synthesis. 7 cl, 2 tbl, 24 ex