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(19)

RU

(11)

2 545 021

(13)

C1

(51)

IPC

C07D213/79(2006-01-01)

C07D213/803(2006-01-01)

A01N43/40(2006-01-01)

A01P13/00(2006-01-01)

(21) (22)

Application

2013139300/04, 2012-01-24

(24)

Start date

2012-01-24

(22)

Actual filing date

2012-01-24

(45)

Published

2015-03-27

(72)

Inventor

Arndt Kim Eh.Renga Dzhejms M.Chzhu Juan'MinUajteker Gregori T.Lou Kristian T.

(73)

Holder

Dau Agrosajensiz Ehlehlsi

METHOD OF OBTAINING 4-AMINO-3-CHLORO-5-FLUORO-6-(SUBSTITUTED)PICOLINATES Russian patent published in 2015 - IPC C07D213/79 C07D213/803 A01N43/40 A01P13/00 

Abstract RU 2545021 C1

FIELD: chemistry.

SUBSTANCE: invention relates to a method of obtaining 4-amino-3-chloro-5-fluoro-6-(substituted)picolinate of formula I where R stands for (C1-C4)alkyl, cyclopropyl, (C2-C4)alkenyl or phenyl, which contains from 1 to 4 substituents, as such independently selected are: a halogen, (C1-C4)alkyl, (C1-C4)halogenalkyl, (C1-C4)alkoxy or (C1-C4)halogenalkoxy; R1 stands for (C1-C12)alkyl or non-substituted or substituted (C7-C11)arylalkyl; which includes the following stages: a) fluorination of 3,4,5,6-tetrachloropicolinonitrile by a source of fluoride-ions, b) amination of 3-chloro-4,5,6-trifluoro-2-picolinonitrile with ammonia, c) substitution of fluorine-substituent in position 6 with 4-amino-3-chloro-5,6-difluoropicolinonitrile by means of hydrogen bromide (HBr), hydrogen chloride (HCl) or hydrogen iodide (HI) and nitrile hydrolysis, d) etherification of 4-amino-3-chloro-5-fluoro-6-halogenpicolineamide by a strong acid and alcohol (R1OH) and e) combination of 4-amino-3-chloro-5-fluoro-6-halogenpicolinate of formula E with an aryl-, alkyl- or alkenylmetalorganic compound.

EFFECT: obtaining the target product with the high output.

2 cl, 4 ex

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RU 2 545 021 C1

Authors

Arndt Kim Eh.

Renga Dzhejms M.

Chzhu Juan'Min

Uajteker Gregori T.

Lou Kristian T.

Dates

2015-03-27—Published

2012-01-24—Filed

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